Osborn, O., Sanchez-Alavez, M., Dubins, J.S., Gonzalez, A.S., Morrison, B., Hadcock, J.R., and Bartfai, T. (2011) AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin. Klein, I., Sanchez-Alavez, M., Tabarean, I., Schaefer, J., Holmberg, K.H., Klaus, J., Xia, F., Marcondes, M.C., Dubins, J.S., Morrison, B., et al. (2011) Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Nomura, D.K.#, Morrison, B.E.#, Blankman, J.L., Long, J.Z., Kinsey, S.G., Marcondes, M.C., Ward, A.M., Hahn, Y.K., Lichtman, A.H., Conti, B., et al. Science translational medicine 4(142):142ra97. (2012) PGC-1α rescues Huntington’s disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Tsunemi T., Ashe T.D., Morrison, B.E., Soriano K.R., Au J., Roque R.A., Lazarowski E.R., Damian V.A., Masliah E., La Spada A.R., et al. The Journal of Immunology (Cutting Edge article) 189(12):5498-502. (2012) IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress–mediated loss following chronic systemic treatment with lipopolysaccharide. Morrison, B.E.#, Marcondes, M.C.#, Nomura, D.K., Sanchez-Alavez, M., Sanchez-Gonzelez, A., Saar, I., Kim, K.S., Bartfai, T., Maher, P., Sugama, S., Conti, B. (2014) Let-7 coordinately suppresses components of the amino acid sensing pathway to induce autophagy. PMID: 25769314ĭubinsky, A., Dastidar, S., Hsu, C., Zahra, R., Djakovic, S., Duarte, S., Esau, C., Spencer, B., Ashe, T., Fische, K., MacKenna, D., Sopher, B., Masliah, E., Gaasterland, T., Chau, B.N., Pereira de Almeida, L., Morrison, B.E., La Spada, A.R. (2015) Parkinson’s disease and enhanced inflammatory response. Stojkovska, I., Wagner, B., and Morrison, B.E. (2015) Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization. PMID: 26806039Įschbach, J., von Einem, B., Müller, K., Bayer, H., Scheffold, A., Morrison, B.E., Rudolph, K.L., Thal, D.R., Witting, A., Weydt, P., Otto, M., Fauler, M., Liss, B., McLean, P.J., La Spada, A.R., Ludolph, A.C., Weishaupt, J.H., Danzer, K.M. (2016) Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice.
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(2016) Discovery of nigral dopaminergic neurogenesis in adult mice. Int J Physiol Pathophysiol Pharmacol 9(2):40-57. (2017) Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer’s disease brain. Love, J.E., Day, R.J., Gause, J.W., Brown, R.J., Pu, X., Theis, D.I., Caraway, C.A., Poon, W.W., Rahman, A.A., Morrison, B.E., Rohn, T.T. My lab’s interest is in understanding the contributions of stem cell activity, autophagy dysfunction, and heightened inflammatory response to neuronal loss in PD so that targeted therapies can be developed.
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As a result, no effective treatments exist that address neurodegeneration in PD. However, the molecular mechanisms underlying this neuronal loss are currently unknown. The clinical motor features of Parkinson’s disease (PD) arise from loss of dopaminergic (DA) neurons in the substantia nigral region of the brain.